منابع مشابه
Transplacental transfer of genotoxins and transplacental carcinogenesis.
A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages. Carcinogens may be direct acting or may require metabolic oxidation such as those in tobacco smoke. Activation can o...
متن کاملTransplacental arsenic carcinogenesis in mice.
Our work has focused on the carcinogenic effects of in utero arsenic exposure in mice. Our data show that a short period of maternal exposure to inorganic arsenic in the drinking water is an effective, multi-tissue carcinogen in the adult offspring. These studies have been reproduced in three temporally separate studies using two different mouse strains. In these studies pregnant mice were trea...
متن کاملTransplacental and Lactational Carcinogenesis by Safrole1
The carcinogenicity of safrole following transplacental ex posure of the mouse fetus and exposure of the neonatal mouse via the mother's milk was investigated in C57BL/6J x CSHeB/ FeJ F, (hereafter called B6C3F,) mice by intragastric admin istration of the agent to pregnant and lactating C57BL/6J females. Safrole (120 ftg/g body weight per treatment) was administered to (a) pregnant mice (4 tim...
متن کاملCarcinogenesis by urethan via mother's milk and its enhancement of transplacental carcinogenesis in mice.
Pulmonary tumors were induced in mice that were suckled by mothers that received urethan during lactation. More induced tumors appeared in sucklings when urethan was injected into lactating mothers soon after delivery. When pregnant mice were treated with urethan during gestation and lactation their offspring had a significantly increased incidence of pulmonary tumors, and the number of tumors ...
متن کاملCarcinogenesis by Urethan Via Mother's Milk and Its Enhancement of Transplacental Carcinogenesis in Mice1
Pulmonary tumors were induced in mice that were suckled by mothers that received urethan during lactation. More induced tumors appeared in sucklings when urethan was injected into lactating mothers soon after delivery. When pregnant mice were treated with urethan during gestation and lactation their offspring had a significantly increased incidence of pulmonary tumors, and the number of tumors ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1974
ISSN: 0021-9746
DOI: 10.1136/jcp.27.4.339-b